The LIFE SIRIUS project was proudly presented at one of the most influential gatherings for climate and health researchers worldwide: ICUC12 in Rotterdam. Representing the project, Prof. Theo Economou and Dr. Daphne Parliari showcased cutting-edge methodologies and scientific findings on the synergistic impacts of air pollution and thermal stress on public health.
Presentation 1: A Statistical Approach to Synergistic Environmental Health Impacts
Presented by: Prof. Theo Economou
Theo Economou introduced an advanced statistical modeling framework that captures the synergistic, temporally distributed effects of multiple environmental stressors on health outcomes.

Key highlights:
- Utilized Distributed Lag Models (DLMs) implemented through penalized regression splines in Generalized Additive Models (GAMs).
- Built using the mgcv package in R, the models can accommodate both continuous (e.g. pollutant concentrations) and categorical exposures (e.g. heatwaves) within hierarchical structures.
- Case studies:
- Cyprus: Heat- and cold-related mortality risk and its amplification during extreme weather events.
- Chicago: Interaction between temperature and PM₁₀ over varying lag periods, highlighting combined exposure effects.
This approach equips researchers and public health authorities with a flexible yet powerful tool to understand and respond to environmental health threats under a changing climate.
Presentation 2: Mortality Burden from Synergistic Air Quality and Bioclimate Extremes
Presented by: Dr. Daphne Parliari
Daphne Parliari focused on the city of Thessaloniki and the combined impact of thermal conditions (via mPET) and air pollution (PM₁₀, NO₂, O₃) on mortality—stratified by age group, season, and urban sub-region.

Key findings:
- Seniors consistently faced higher attributable fractions (AFs) of mortality under both heat and cold stress, particularly when combined with elevated NO₂ and PM₁₀, especially in colder months.
- Health risks associated with air pollution tended to increase during warmer periods, especially under extreme thermal conditions.
- Certain urban areas experienced a greater health burden due to a combination of elevated pollution levels and more frequent or intense extreme weather events.
🔍 These findings offer granular, evidence-based recommendations for early warning systems and targeted heat-health action plans, highlighting the necessity of integrating climate-health interlinkages at the urban level.
LIFE SIRIUS: Scaling Science into Policy
The participation of LIFE SIRIUS at ICUC12 illustrates the project’s strong contribution to the interface between science, forecasting tools, and public health policy. As climate stressors intensify, the need for actionable, locally tailored responses becomes ever more pressing.
LIFE SIRIUS continues to build this bridge—providing European cities with methodologies, forecasting capacity, and risk communication strategies to protect vulnerable populations from combined environmental hazards.








